Nightcap

A lice outbreak forces the whole staff to be treated, causing Whoopi Goldberg to draw the wrong conclusion about the staff members' treatment hairstyles; booked guest Denis Leary calls in sick, but Staci isn't having it.

Staci tries to convince a reluctant Michael J. Fox to allow himself to be shot out of a cannon on the show; Jim Gaffigan does everything in his power to hawk his new energy drink, EnerrJesus, on "Nightcap."

Todd tries to persuade Debra Messing to make a video in character as Grace; Tim Gunn pops by the studio claiming Jimmy asked him to make an appearance; Randy and Marcus are excited to pitch their new invention to "Shark Tank's" Mark Cuban.

Everyone is excited to see actor Jason Biggs again, but it turns out he's become a completely different person since the last time he was on the show; actress Beth Stern brings kittens that are available for adoption, then one goes missing.

Staci tries to convince transgender celebrity GiGi Gorgeous to go on a date with Jimmy; Ana pitches her makeup line and wants Stephanie March to be her new spokesperson; Janeane Garofalo is dismayed by Jimmy's sexist sketch.

Chef Mario Batali tries to aid Staci as she struggles through a horrible bout of irritable bowel syndrome; journalist George Stephanopoulos schools Penny on ISIS, an organization she believes is trying to recruit her.

Jimmy starts a GoFundMe campaign to make a biographical film, and Staci's job is to convince actor Paul Rudd to play "Jimmy" in the film; Wendy Williams bonds with an unlikely person over her wig collection.

Staci seriously considers leaving "Nightcap;" actress Mariska Hargitay agrees to be eaten by an anaconda on air; Todd directs his first shoot starring actress Rosie Perez, until film director Joel Schumacher intervenes.